Mohsペーストの医療ニーズを通じ基礎研究から臨床応用までの検討について

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タイトル別名
  • Clinical Application of Basic Research on Mohs' Paste to Meet Medical Needs
  • Symposium Review : Mohsペーストの医療ニーズを通じ基礎研究から臨床応用までの検討について
  • Symposium Review : Mohs ペースト ノ イリョウ ニーズ オ ツウジ キソ ケンキュウ カラ リンショウ オウヨウ マデ ノ ケントウ ニ ツイテ

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　Mohs' paste (MP), which is widely used in medical services as a specific hospital preparation, has been considered to have demerits, such as increased hardness after preparation and marked adhesiveness. However, factors associated with variations in its physical properties have not yet been clarified. Therefore, we conducted studies to clarify the physicochemical phenomena influencing such variations, and also examined prescription drug designs of MP preparations that are difficult to use clinically due to the above-mentioned demerits, with a view to improving their usability. Furthermore, with cooperation from the director of the Department of Palliative Care and Maintenance Therapy and certified wound ostomy and continence (WOC) nurses of Yokohama Minami Kyousai Hospital, we clinically applied an improved form of MP I. We also examined the effects of an improved MP II (designed as a stable formulation) in mice. This is an example of the clinical application of basic research to design a new clinical formulation in order to meet medical needs.<br>

収録刊行物

  • 薬学雑誌

    薬学雑誌 138 (6), 773-780, 2018-06-01

    公益社団法人 日本薬学会

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