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- Shimasaki Takeo
- Medical Research Institute, Kanazawa Medical University Department of Gastroenterology, Kanazawa Medical University Ginreilab Inc.
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- Yamamoto Satoko
- Medical Research Institute, Kanazawa Medical University
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- Arisawa Tomiyasu
- Department of Gastroenterology, Kanazawa Medical University
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抄録
<p>In biological systems, extracellular vesicles including exosomes have recently been revealed to play a significant role in the communication between various cells, and the number of papers on this subject has dramatically increased. In current conventional exosome studies, the standard research method is to use liquid biopsies to analyze extracts of various disease exosomes. However, exosomes are only one of many key players in natural cellular interactions. Reproducing the phenomena occurring in vivo and investigating the interactions are required in order to examine their role fully. For exosome research, an alternative to the liquid biopsy method for observing natural interactions is the co-culturing technique. It does not require an exosome extraction procedure, and while the technique has been used in many studies thus far, its application to exosome research has been limited. However, the use of co-culturing technologies is necessary to examine the essential interactions of exosomes. An overview of exosome research methodologies and co-culturing systems is thus provided here.</p>
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 41 (9), 1311-1321, 2018-09-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001288063830528
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- NII論文ID
- 130007479891
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 029184866
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- PubMed
- 30175767
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可