A Case of Metachronous Bilateral Breast Cancer Associated with Neurofibromatosis Type1（NF1）and Situs Inversus Totalis

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  • MURAKAMI Yuko
    Department of Surgery, Hoshi General Hospital Departments of Breast Surgery, Fukushima Medical University
  • MOMMA Tomoyuki
    Department of Surgery, Hoshi General Hospital Gastrointestinal Tract Surgery, Fukushima Medical University
  • TACHIBANA Kazunoshin
    Department of Surgery, Hoshi General Hospital Departments of Breast Surgery, Fukushima Medical University
  • NAGATSUKA Miki
    Department of Surgery, Hoshi General Hospital
  • MATSUZAKI Masami
    Department of Surgery, Hoshi General Hospital
  • NOMIZU Tadashi
    Department of Surgery, Hoshi General Hospital

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Other Title
  • 神経線維腫症1型および完全内臓逆位症を伴った異時性両側乳癌の1例
  • 症例 神経線維腫症1型および完全内臓逆位症を伴った異時性両側乳癌の1例
  • ショウレイ シンケイ センイ シュショウ 1ガタ オヨビ カンゼン ナイゾウ ギャクイショウ オ トモナッタ イジセイ リョウガワ ニュウガン ノ 1レイ

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Abstract

We report an extremely rare and suggestive case of metachronous bilateral breast cancer associated with neurofibromatosis type1 (NF1) and complete visceral inversion (situs inversus totalis). Metachronous left breast cancer occurred 10 years after right breast cancer which was non-palpable carcinoma detected by screening examinations. She had an identical twin who also developed breast cancer. It was suggestive that twin sisters from a family with NF1 had breast cancer NF1 also called von Recklinghausen disease is an autosomal dominant hereditary disease characterized by multiple café au lait spots, axillary and inguinal freckling and multiple cutaneous neurofibromas. It is caused by mutations in the NF1 gene which is located on chromosome 17q. Recently NF1 is recognized as one of the hereditary cancer predisposition syndromes. Therefore, recognition of this syndrome has significant importance of cancer screening.

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