α-Tocopherol Intake Decreases Phylloquinone Concentration in Bone but Does Not Affect Bone Metabolism in Rats
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- IKEDA Saiko
- Department of Nutritional Sciences, Nagoya University of Arts and Sciences
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- NOMURA Saki
- Department of Nutritional Sciences, Nagoya University of Arts and Sciences
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- HANZAWA Fumiaki
- Department of Nutritional Sciences, Nagoya University of Arts and Sciences
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- TAKAHASHI Saki
- Department of Nutritional Sciences, Nagoya University of Arts and Sciences
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- ODA Hiroaki
- Department of Applied Molecular Biosciences, Nagoya University
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- FUJIWARA Yoko
- Department of Nutrition and Food Science, Ochanomizu University
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- UCHIDA Tomono
- Department of Home Economics, Aichi Gakusen University
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Description
Previous studies have shown that α-tocopherol intake lowers phylloquinone (PK) concentration in some extrahepatic tissues in rats. The study’s aim was to clarify the effect of α-tocopherol intake on vitamin K concentration in bone, as well as the physiological action of vitamin K. Male Wistar rats were divided into 4 groups. Over a 3-mo period, the K-free group was fed a vitamin K-free diet with 50 mg RRR-α-tocopherol/kg, the E-free group was fed a diet containing 0.75 mg PK/kg without vitamin E, the control group was fed a diet containing 0.75 mg PK/kg with 50 mg RRR-α-tocopherol/kg, and the E-excess group was fed a diet containing 0.75 mg PK/kg with 500 mg RRR-α-tocopherol/kg. PK concentration in the liver was higher in E-excess rats than in E-free rats, was lower in the tibias of control rats than in those of E-free rats, and was lower in E-excess rats than in control rats. Menaquinone-4 (MK-4) concentration in the liver was higher in E-excess rats than in E-free and control rats. However, MK-4 concentrations in the tibias of E-free, control, and E-excess rats were almost the same. Blood coagulation activity was lower in K-free rats than in the other rats but was not affected by the level of α-tocopherol intake. Additionally, dietary intake of PK and α-tocopherol did not affect uncarboxylated-osteocalcin concentration in the serum, femur density, or expression of the genes related to bone resorption and formation in the femur. These results suggest that α-tocopherol intake decreases PK concentration in bone but does not affect bone metabolism in rats.
Journal
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 64 (4), 243-250, 2018
Center for Academic Publications Japan
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Details 詳細情報について
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- CRID
- 1390001288067120512
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- NII Article ID
- 130007472700
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- NII Book ID
- AA00703822
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- ISSN
- 18817742
- 03014800
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- NDL BIB ID
- 029177579
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- PubMed
- 30175786
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed