Participation of intracellular vesicular trafficking in acute pancreatitis

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  • 3．急性膵炎発症・進展における細胞内膜小胞輸送の役割

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<p>Pancreatic acinar cells synthesize a variety of digestive enzymes and secrete them into the pancreatic duct. Intracellular vesicle transport mechanisms play important roles in maintaining these functions. Exocytosis, autophagy and endocytosis are representative of intracellular vesicle trafficking in pancreatic acinar cells. These intracellular vesicular trafficking systems are mediated by soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins, autophagy-related genes and the Ras-related GTP-binding protein Rab family. Recent studies demonstrated that defects in intracellular vesicular trafficking systems including exocytosis, autophagy and endocytosis are involved in the onset and progression of acute pancreatitis. These intracellular trafficking pathways are closely related to each other. Therefore, in order to elucidate the pathophysiological mechanisms of acute pancreatitis, it is important to investigate the interactions as well as the participation of each pathway in the onset and progression of acute pancreatitis.</p>

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  • Suizo

    Suizo 33 (4), 723-729, 2018-08-25

    Japan Pancreas Society

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