Evaluation of Clinical Features and Growth Hormone Deficiency in Short Children Born Small For Gestational Age

  • IKEGAMI Tomomi
    Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Japan.
  • ARAKI Shunsuke
    Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Japan.
  • KUWAMURA Mami
    Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Japan.
  • TAKU Aoi
    Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Japan.
  • SAITO Reiko
    Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Japan.
  • GOTO Motohide
    Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Japan.
  • KUBO Kazuyasu
    Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Japan.
  • KAWAGOE Rinko
    Department of Pediatrics, Tobata General Hospital , Japan
  • YAMAMOTO Yukiyo
    Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Japan.
  • KAWADA Yasusada
    Department of Pediatrics, Kyushu Rosai Hospital , Japan
  • KUSUHARA Koichi
    Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Japan.

Bibliographic Information

Other Title
  • Small for Gestational Age児における成長ホルモン分泌不全の合併についての検討
  • Small for Gestational Ageジ ニ オケル セイチョウ ホルモン ブンピ フゼン ノ ガッペイ ニ ツイテ ノ ケントウ

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Abstract

Growth hormone (GH) therapy for short children born small for gestational age (SGA) has been approved in Japan. It is important to evaluate GH secretion ability before the initiation of GH therapy because there are some differences in dose and medical expenses between short children born SGA and GH deficiency (GHD). This study was designed to elucidate the incidence of GHD and to find a useful marker for detecting it in short SGA children. We retrospectively reviewed medical records to analyze the clinical features of short children born SGA and with GHD who had started GH therapy before the age of 6 in the University Hospital of Occupational and Environmental Health and Kyushu Rousai Hospital. Nine of 22 SGA subjects (41%) had GHD. There were no significant differences between two groups of short SGA children (GHD, non-GHD) in the median of height and serum insulin-like growth factors (IGF)-1 levels at birth or at the start of GH therapy. The probability of GHD was higher if the height standard deviation scores (SD) of the SGA children were lower than −3.2 (odds ratio, 11.6; 95% confidence interval, 1.52 − 89.1, P = 0.013). This study showed that there is an approximately 40% incidence of GHD in short SGA children needing GH treatment. We should do GH stimulation tests for short SGA children whose height SD is lower than -3 to determine the appropriate GH therapy.

Journal

  • Journal of UOEH

    Journal of UOEH 40 (3), 253-257, 2018-09-01

    The University of Occupational and Environmental Health, Japan

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