ADMINISTRATION OF FIBRINOGEN CONCENTRATE REDUCED TRANSFUSION VOLUME IN CADAVERIC LIVER TRANSPLANTATION SURGERY

DOI Web Site 4 References Open Access
  • Uwatoko Takayo
    Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital
  • Hayase Eiko
    Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital Department of Hematology, Hokkaido University Faculty of Medicine
  • Kahata Kaoru
    Clinical Research and Medical Innovation Center, Hokkaido University Hospital Department of Hematology, Hokkaido University Faculty of Medicine
  • Hashimoto Daigo
    Department of Hematology, Hokkaido University Faculty of Medicine
  • Ito Makoto
    Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital
  • Uozumi Ryo
    Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital
  • Hayashi Yasuhiro
    Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital
  • Sugita Junichi
    Department of Hematology, Hokkaido University Faculty of Medicine
  • Koshizuka Yasuyuki
    Department of Gastroenterological Surgery I, Hokkaido University Hospital
  • Goto Ryoichi
    Department of Gastroenterological Surgery I, Hokkaido University Hospital
  • Watanabe Chiaki
    Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital
  • Akizawa Koji
    Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital
  • Shimamura Tsuyoshi
    Division of Organ Transplantation, Hokkaido University Hospital
  • Shimizu Chikara
    Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital
  • Teshima Takanori
    Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital Department of Hematology, Hokkaido University Faculty of Medicine

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Other Title
  • 脳死肝移植時のフィブリノゲン製剤使用による術中出血量と輸血使用量に関する検討

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<p>Background: Liver transplantation is associated with massive bleeding and transfusion in recipients with coagulopathy. A previous study reported that intraoperative fibrinogen concentrate (IOFC) reduces transfusion volume in liver transplant procedures. In our institute, IOFC was introduced in 2012 for preventing massive bleeding in cadaveric liver transplantation. We studied the effects of IOFC on the amount of bleeding and transfusion during surgery.</p><p>Patients andMethods: We retrospectively analyzed 44 adult patients who underwent cadaveric liver transplantation between February 2001 and August 2016. The amount of intraoperative bleeding and transfusion in 25 transplantations that did not use IOFC was compared to that in 19 cases that used IOFC. We also analyzed 33 patients who bled more than their circulating blood volume (16 cases without IOFC, 17 cases with IOFC).</p><p>Results: The amount of intraoperative bleeding and transfusion was not significantly different between the two groups. In sub-analysis of 33 patients who bled more than their circulating blood volume, the amount of intraoperative bleeding was significantly reduced in the group that used IOFC. Further, the amount of intraoperative PC transfusion was significantly reduced and the amount of red blood cells and fresh frozen plasma tended to be lower.</p><p>Conclusion: Use of IOFC reduced intraoperative massive hemorrhage and PC requirements in cadaveric liver transplantation.</p>

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