A Case of Malignant Granular Cell Tumor Originated from the Inguinal Subcutaneous Tissue

Endo Shunji, Yamada Terumasa, Ikenaga Masakazu, Adachi Shinichi, Ohta Katsuya, Nakashima Shinsuke, Ueda Masami, Tsuda Yujiro, Itakura Hiroaki, Yamauchi Amane

doi:10.4030/jjcs.42.886

<p>A 77-year-old woman exhibited a left inguinal tumor and aspiration biopsy cytology revealed that it was a poorly differentiated carcinoma. Positron emission tomography demonstrated uptake of fluorodeoxyglucose to the cervical spine, left subclavicular lymph nodes, bilateral lungs, bilateral hilar lymph nodes, paraaortic lymph nodes, left iliac lymph nodes, and left inguinal lymph nodes. An incisional biopsy of the left inguinal tumor revealed that it was cancer of unknown primary origin. Chemotherapy with carboplatin and etoposide was not effective. She died seven months after the first visit to a neighborhood clinic. Autopsy demonstrated multiple tumors in the subcutaneous tissue in the lower abdomen and the left groin, the bilateral lungs, pleura, diaphragm, liver, serosa of the intestine, mesenterium, and pelvis, as well as swollen mediastinal and paraaortic lymph nodes. Histologically, the tumors were of the same type. Tumor cells exhibited large, oblong, spindle-shaped, or irregular nuclei and abundant granular cytoplasm. They were positive for Vimentin, S-100, NSE, and Laminin, and partially positive for CD68. They were considered to be malignant granular cell tumors. The origin was considered to be the left inguinal subcutaneous tissue.</p>

A Case of Malignant Granular Cell Tumor Originated from the Inguinal Subcutaneous Tissue

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