The kinematic recovery process of rhesus monkeys after spinal cord injury

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  • Wei Rui-Han
    Beijing Key Laboratory for Biomaterials and Neural Regeneration, School of Biological Science and Medical Engineering, Beihang University, No. 37 Xueyuan Road, Haidian District, Beijing 100083, P.R. China
  • Zhao Can
    Beijing Key Laboratory for Biomaterials and Neural Regeneration, School of Biological Science and Medical Engineering, Beihang University, No. 37 Xueyuan Road, Haidian District, Beijing 100083, P.R. China Beijing International Cooperation Bases for Science and Technology on Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University, No. 37 Xueyuan Road, Haidian District, Beijing 100083, P.R. China School of Instrument Science and Opto-Electronic Engineering, Beihang University, No. 37 Xueyuan Road, Haidian District, Beijing 100083, P.R. China
  • Rao Jia-Sheng
    Beijing Key Laboratory for Biomaterials and Neural Regeneration, School of Biological Science and Medical Engineering, Beihang University, No. 37 Xueyuan Road, Haidian District, Beijing 100083, P.R. China Beijing International Cooperation Bases for Science and Technology on Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University, No. 37 Xueyuan Road, Haidian District, Beijing 100083, P.R. China Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, No. 37 Xueyuan Road, Haidian District, Beijing 100083, P.R. China
  • Zhao Wen
    Department of Neurobiology, Capital Medical University, No. 10 Xitoutiao Road, Youanmenwai, Xicheng District, Beijing 100191, P.R. China
  • Zhou Xia
    Beijing Key Laboratory for Biomaterials and Neural Regeneration, School of Biological Science and Medical Engineering, Beihang University, No. 37 Xueyuan Road, Haidian District, Beijing 100083, P.R. China
  • Tian Peng-Yu
    Beijing Key Laboratory for Biomaterials and Neural Regeneration, School of Biological Science and Medical Engineering, Beihang University, No. 37 Xueyuan Road, Haidian District, Beijing 100083, P.R. China
  • Song Wei
    Rehabilitation Engineering Research Institute, China Rehabilitation Research Center, No. 10 Jiaomenbei Road, Fengtai District, Beijing 100068, P.R. China
  • Ji Run
    Human Biomechanics Laboratory, National Research Center for Rehabilitation Technical Aids, No. 1 Ronghuazhong Road, Daxing District, Beijing 100176, P.R. China
  • Zhang Ai-Feng
    Beijing Friendship Hospital, Capital Medical University, No. 95 Yongan Road, Xicheng District, Beijing 100050, P.R. China
  • Yang Zhao-Yang
    Beijing Key Laboratory for Biomaterials and Neural Regeneration, School of Biological Science and Medical Engineering, Beihang University, No. 37 Xueyuan Road, Haidian District, Beijing 100083, P.R. China Department of Neurobiology, Capital Medical University, No. 10 Xitoutiao Road, Youanmenwai, Xicheng District, Beijing 100191, P.R. China
  • Li Xiao-Guang
    Beijing Key Laboratory for Biomaterials and Neural Regeneration, School of Biological Science and Medical Engineering, Beihang University, No. 37 Xueyuan Road, Haidian District, Beijing 100083, P.R. China Beijing International Cooperation Bases for Science and Technology on Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University, No. 37 Xueyuan Road, Haidian District, Beijing 100083, P.R. China Department of Neurobiology, Capital Medical University, No. 10 Xitoutiao Road, Youanmenwai, Xicheng District, Beijing 100191, P.R. China

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<p>After incomplete spinal cord injury (SCI), neural circuits may be plastically reconstructed to some degree, resulting in extensive functional locomotor recovery. The present study aimed to observe the post-SCI locomotor recovery of rhesus monkey hindlimbs and compare the recovery degrees of different hindlimb parts, thus revealing the recovery process of locomotor function. Four rhesus monkeys were chosen for thoracic hemisection injury. The hindlimb locomotor performance of these animals was recorded before surgery, as well as 6 and 12 weeks post-lesion. Via principal component analysis, the relevant parameters of the limb endpoint, pelvis, hindlimb segments, and joints were processed and analyzed. Twelve weeks after surgery, partial kinematic recovery was observed at the limb endpoint, shank, foot, and knee joints, and the locomotor performance of the ankle joint even recovered to the pre-lesion level; the elevation angle of the thigh and hip joints showed no obvious recovery. Generally, different parts of a monkey hindlimb had different spontaneous recovery processes; specifically, the closer the part was to the distal end, the more extensive was the locomotor function recovery. Therefore, we speculate that locomotor recovery may be attributed to plastic reconstruction of the motor circuits that are mainly composed of corticospinal tract. This would help to further understand the plasticity of motor circuits after spinal cord injury.</p>

収録刊行物

  • Experimental Animals

    Experimental Animals 67 (4), 431-440, 2018

    公益社団法人 日本実験動物学会

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