Preparation of Complexes between Ovalbumin Nanoparticles and Retinoic Acid for Efficient Induction of Tolerogenic Dendritic Cells

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  • ZAI Khadijah
    Department of Applied Chemistry, Faculty of Engineering, Kyushu University
  • YUZURIHA Kazuki
    Graduate School of Systems Life Sciences, Kyushu University
  • KISHIMURA Akihiro
    Department of Applied Chemistry, Faculty of Engineering, Kyushu University Graduate School of Systems Life Sciences, Kyushu University Center for Future Chemistry, Kyushu University International Research Center for Molecular Systems, Kyushu University
  • MORI Takeshi
    Department of Applied Chemistry, Faculty of Engineering, Kyushu University Graduate School of Systems Life Sciences, Kyushu University Center for Future Chemistry, Kyushu University
  • KATAYAMA Yoshiki
    Department of Applied Chemistry, Faculty of Engineering, Kyushu University Graduate School of Systems Life Sciences, Kyushu University Center for Future Chemistry, Kyushu University International Research Center for Molecular Systems, Kyushu University Centre for Advanced Medicine Innovation, Kyushu University Department of Biomedical Engineering, Chung Yuan Christian University

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<p>The induction of antigen-specific immunotolerance has been gathering attention concerning the therapy of allergy and autoimmune diseases. Tolerogenic dendritic cells (tDCs) play crucial roles in immunotolerance therapy because they induce anergic responses for auto-reactive helper T cells, and also enhance differentiation to regulatory T cells to maintain tolerance against auto-antigens. All-trans retinoic acid (ATRA) is one of the representative molecules used to induce tDCs. We have proposed a simple formulation of ovalbumin nanoparticles complexed with ATRA (OVA/RA NPs). OVA/RA NPs were taken up by DCs and successfully induced phenotypes of tDCs.</p>

収録刊行物

  • Analytical Sciences

    Analytical Sciences 34 (11), 1243-1248, 2018-11-10

    社団法人 日本分析化学会

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