Recurrent Varicella in a Patient with Systemic Lupus Erythematosus Treated with Immunosuppressants

DOI Web Site Web Site 3 References
  • KIMURA Nanae
    Department of Dermatology and Allergy, Kyushu Medical Center Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
  • URABE Kazunori
    Department of Dermatology and Allergy, Kyushu Medical Center
  • FURUE Masutaka
    Department of Dermatology, Graduate School of Medical Sciences, Kyushu University

Bibliographic Information

Other Title
  • 免疫抑制治療中の SLE 患者に生じた再発性水痘
  • 症例 免疫抑制治療中のSLE患者に生じた再発性水痘
  • ショウレイ メンエキ ヨクセイ チリョウ チュウ ノ SLE カンジャ ニ ショウジタ サイハツセイ スイトウ

Search this article

Abstract

<p>A 33-year-old female with systemic lupus erythematosus and antiphospholipid antibody syndrome visited our department due to having disseminated purpuric vesicles of a few-day history. She had been treated with a combination of immunosuppressive drugs ; prednisolone 25 mg/day, mycophenolate mofetil 1500 mg/day, and tacrolimus 1. 5 mg/day. Histological examination of a vesicle suggested a herpetic infection. Laboratory examination showed high titers of IgG antibodies against herpes simplex virus (HSV) and varicella zoster virus (VZV) on the first day, neglecting primary herpetic infections. The oral administration of valaciclovir 1000 mg 3 times a day for a week was successful and all her vesicles crusted and healed. No significant changes were seen in the antibody titers of HSV and VZV at 3 and 11 weeks after the onset, and the VZV-IgM and HSV-IgM antibodies were not detected throughout the clinical course. However, the VZV antigen was positively stained in the nuclei of affected keratinocytes by immunohistological examination, leading to a final diagnosis of recurrent varicella. The reactivation of VZV usually causes herpes zoster, while it may directly induce recurrent varicella without any association with a localized zosteriform eruption, especially in elderly or immunocompromised patients.</p>

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 80 (4), 354-357, 2018-08-01

    Western Division of Japanese Dermatological Association

References(3)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top