Microflow Fluorinations of Benzynes: Efficient Synthesis of Fluoroaromatic Compounds

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  • Ikawa Takashi
    Graduate School of Pharmaceutical Sciences, Osaka University
  • Masuda Shigeaki
    Graduate School of Pharmaceutical Sciences, Osaka University
  • Akai Shuji
    Graduate School of Pharmaceutical Sciences, Osaka University

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  • Highlighted Paper selected by Editor-in-Chief : Microflow Fluorinations of Benzynes : Efficient Synthesis of Fluoroaromatic Compounds

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<p>Fluorinated aromatic compounds are found in a variety of biologically active compounds, including clinical drugs and agrochemicals. Therefore, the synthesis of aryl fluorides is particularly important in the medicinal and process chemistry fields. In this paper, we report a method for the synthesis of aryl fluorides by benzyne fluorination under microflow conditions using the efficient Comet X-01 micromixer. In comparison to our previously reported method under ordinary batch conditions, this approach facilitates a significant reduction in reaction times, to ca. 10 s, as well as increases in the yields of fluoroarenes (by up to 51%).</p>

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