Studies on Biological Functions of Lipids

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  • Zaima Nobuhiro
    Faculty of Agriculture, Kindai University Agricultural Technology and Innovation Research Institute, Kindai University

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  • 機能性脂質の生体調節作用に関する研究
  • 機能性脂質の生体調節作用に関する研究(平成30年度日本栄養・食糧学会奨励賞受賞)
  • キノウセイ シシツ ノ セイタイ チョウセツ サヨウ ニ カンスル ケンキュウ(ヘイセイ 30ネンド ニホン エイヨウ ・ ショクリョウ ガッカイ ショウレイショウ ジュショウ)
  • (JSNFS Young Investigator Award (2018))
  • (平成30年度日本栄養・食糧学会奨励賞受賞)

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Abstract

<p>Abdominal aortic aneurysm (AAA) is a vascular disease characterized by gradual dilation of the abdominal aorta. It has been reported that AAA diameter is positively correlated with the risk of AAA rupture. However, the mechanisms of AAA onset and development are not fully understood. In addition, no current drug therapy can prevent the onset of aneurysm development or rupture. Recently, a number of different studies, including research emanating from our research group, have demonstrated that administration of fish oil can prevent the development and rupture of AAA. We have also previously found that stenosis of the vasa vasorum can cause onset of AAA and that abnormal appearance of adipocytes in the AAA wall can induce AAA rupture. In this review, we summarize the method of matrix-assisted laser desorption ionization mass spectrometry imaging utilized in our study and then discuss the potential mechanism leading to the rupture of AAA and methods for its prevention and treatment.</p>

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