Ifenprodil tartrate treatment of adolescents with Post-traumatic stress disorder: a Double-blind, Placebo-controlled Trial
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- Sasaki Tsuyoshi
- Department of Child Psychiatry, Chiba University Hospital
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- Hashimoto Kenji
- Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health
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- Iyo Masaomi
- Department of Child Psychiatry, Chiba University Hospital Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health Department of Psychiatry, Chiba University Graduate School of Medicine
Bibliographic Information
- Other Title
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- 思春期の心的外傷後ストレス障害(PTSD)患者を対象にしたイフェンプロジル酒石酸塩の有効性を検討するためのプラセボ対照二重盲検比較試験
- シシュンキ ノ シンテキ ガイショウ ゴ ストレス ショウガイ(PTSD)カンジャ オ タイショウ ニ シタ イフェンプロジル シュセキサンエン ノ ユウコウセイ オ ケントウ スル タメ ノ プラセボ タイショウ ニジュウ モウケンヒカク シケン
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Description
Accumulating evidence suggests a key role of the N-methyl-D-aspartate (NMDA) receptor in the pathophysiology of post-traumatic stress disorder (PTSD) . Recent studies suggest that the NMDA receptor antagonist ifenprodil tartrate may be a potential therapeutic drug for PTSD. The purpose of this study is to confirm whether ifenprodil tartrate is effective in the treatment of adolescents (13-18 years old) PTSD patients. If ifenprodil tartrate is effective in these patients, this study contributes to the development of novel therapeutic drugs for PTSD. This study is an interventional, randomized, parallel assignment, double blinded clinical trial. The primary outcome measure is Impact of Event Scale-Revised Japanese Version: IES-R-J and the secondary outcome measure are Trauma Symptom Checklist for Children Japanese Version: TSCC-J, Children’s Depression Rating Scale-Revised: CDRS-R, Depression Self-Rating Scale for Children Japanese Version: DSRS-C-J and CGI-scores. [Time Frame: Changes from baseline in these scores at 4-weeks]
Journal
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- Japanese Journal of Biological Psychiatry
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Japanese Journal of Biological Psychiatry 28 (2), 95-99, 2017
Japanese Society of Biological Psychiatry
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Keywords
Details 詳細情報について
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- CRID
- 1390001288114767232
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- NII Article ID
- 130007582066
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- NII Book ID
- AA12468060
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- ISSN
- 21866465
- 21866619
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- NDL BIB ID
- 028409457
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL Search
- CiNii Articles
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- Abstract License Flag
- Disallowed