Association analyses of eQTLs of the TYRO3 gene and allergic diseases in Japanese populations
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- Kanazawa Jun
- Department of Pulmonary Medicine, University of Tsukuba
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- Masuko Hironori
- Department of Pulmonary Medicine, University of Tsukuba
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- Yatagai Yohei
- Department of Pulmonary Medicine, University of Tsukuba
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- Sakamoto Tohru
- Department of Pulmonary Medicine, University of Tsukuba
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- Yamada Hideyasu
- Department of Pulmonary Medicine, University of Tsukuba
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- Kitazawa Haruna
- Department of Pulmonary Medicine, University of Tsukuba
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- Iijima Hiroaki
- Tsukuba Medical Center
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- Naito Takashi
- Tsukuba Medical Center
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- Saito Takefumi
- National Hospital Organization Ibarakihigashi National Hospital
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- Noguchi Emiko
- Department of Medical Genetics, University of Tsukuba
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- Hirota Tomomitsu
- The Jikei University School of Medicine
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- Tamari Mayumi
- The Jikei University School of Medicine
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- Hizawa Nobuyuki
- Department of Pulmonary Medicine, University of Tsukuba
書誌事項
- タイトル別名
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- Association analyses of eQTLs of the <i>TYRO3</i> gene and allergic diseases in Japanese populations
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<p>Background: TYRO3 is a member of the TAM (TYRO3, AXL, MERTK) receptor tyrosine kinase family and functions to limit type 2 immune responses implicated in allergic sensitization. Recent studies have shown that multiple intronic variants of TYRO3 were associated with asthma, implying that genetic variation could contribute to errant immune activation. We therefore hypothesized that expression quantitative trait loci (eQTLs) of the TYRO3 gene influence the development of allergic diseases (including asthma and allergic rhinitis) in Japanese populations.</p><p>Methods: We performed a candidate gene case-control association study of 8 eQTLs of TYRO3 on atopy, asthma, and allergic rhinitis using 1168 unrelated Japanese adults who had GWAS genotyping. We then examined the genetic impact of rs2297377 (TYRO3) on atopy and allergic rhinitis in 2 other independent Japanese populations.</p><p>Results: A meta-analysis of 3 Japanese populations (a total of 2403 Japanese adults) revealed that rs2297377 was associated with atopy and allergic rhinitis (OR = 1.29 and 1.31; P = 0.00041 and 0.0010, respectively). The risk allele at rs2297377 correlated with decreased expression of TYRO3 mRNA. The gene-gene interaction between HLA-DPB1 and TYRO3 was not significant with regard to sensitization. The estimated proportion of atopy and allergic rhinitis cases attributable to the risk genotype was 14% and 16%, respectively.</p><p>Conclusions: Our study identified TYRO3 as an important susceptibility gene to atopy and allergic rhinitis in Japanese.</p>
収録刊行物
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- Allergology International
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Allergology International 68 (1), 77-81, 2019
一般社団法人日本アレルギー学会
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詳細情報 詳細情報について
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- CRID
- 1390001288118411648
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- NII論文ID
- 130007557962
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- NII書誌ID
- AA11091750
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- ISSN
- 14401592
- 13238930
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- HANDLE
- 2241/00157088
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
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