Teratogenic Effects of Bredinin, a New Immunosuppressive Agent, in Rats
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- OKAMOTO Kyoko
- Research Laboratories, Toyo Jozo
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- KOBAYASHI Yooshiro
- Research Laboratories, Toyo Jozo
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- YOSHIDA Kaoru
- Faculty of Pharmaceuti-cal Sciences, Kobe-Gakuin University
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- NOZAKI Yoshihide
- Faculty of Pharmaceuti-cal Sciences, Kobe-Gakuin University
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- KAWAI Yuichi
- Faculty of Pharmaceuti-cal Sciences, Kobe-Gakuin University
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- KAWANO Hiroko
- Faculty of Pharmaceuti-cal Sciences, Kobe-Gakuin University
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- MAYUMI Tadanori
- Faculty of Pharmaceuti-cal Sciences, Kobe-Gakuin University
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- HAMA Takao
- Faculty of Pharmaceuti-cal Sciences, Kobe-Gakuin University
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Abstract
When bredinin was intraperitoneally injected into pregnant rats on day 11 at 2.5, 5.0, 7.5 and 10.0 mg/kg, fetal mortality was 5.1%, 42.1%, 95.5% and 100%, respectively. Fetal abnormalities were induced in relation to the amount of the administered drug. Next, for the examination of the stage specificity, a dose of 5 mg/kg was administered on various day during the organogenetic period. The drug administration on day 7, 8, 10 or 11 of gestation resulted in a high fetal mortality, while the administration on day 9 caused a relatively low fetal mortality. This result demonstrated that there were two susceptible periods in rat embryonic development to the lethal action of bredinin. There was a close relationship between types of abnormalities and the day of administration : fetuses of rats treated on day 9 of gestation showed a relatively low percentage of skeletal abnormalities and a high percentage of visceral abnormalities. However, in fetuses of those treated on day 8 or 10 of gestation, skeletal abnormalities were marked and visceral abnormalities were relatively scarce.
Journal
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- official journal of Congeital Anomalies Research Association of Japan
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official journal of Congeital Anomalies Research Association of Japan 18 (4), 227-233, 1978-12-30
The Japanese Teratology Society
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Details 詳細情報について
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- CRID
- 1390001288120596480
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- NII Article ID
- 110002726918
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- ISSN
- 24331503
- 00372285
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- Text Lang
- en
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed