Synthetic Aryne Chemistry toward Multicomponent Coupling
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- Yoshida Suguru
- Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
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- Hosoya Takamitsu
- Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
Bibliographic Information
- Other Title
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- 多成分集積を指向した合成のためのアライン化学
- タセイブン シュウセキ オ シコウ シタ ゴウセイ ノ タメ ノ アライン カガク
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Abstract
<p>Arynes with a highly reactive carbon-carbon triple bond are multipotent intermediates useful for preparing various multisubstituted arenes. To further enhance the synthetic utility of arynes, we have developed a wide range of synthetic methods involving aryne intermediates, including novel methods for aryne generation from o-sulfinylaryl triflates and o-iodoaryl triflates using phenyl or silylmethyl Grignard reagent, respectively. These methods allowed for the generation of new types of aryne intermediates that enabled facile syntheses of a wide variety of multisubstituted arenes such as aryl triflates, anilines, and benzoheterols. We also developed several novel transformations involving C-S or C-P bond formation via aryne intermediates, such as thioamination using sulfilimines, and several methods for preparing various o-silylaryl triflate-type aryne precursors that were difficult to be achieved by the conventional methods. These methods were demonstrated useful for preparation of a diverse range of multitriazoles and multisubstituted o-(arylthio)anilines by modular syntheses.</p>
Journal
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- Journal of Synthetic Organic Chemistry, Japan
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Journal of Synthetic Organic Chemistry, Japan 77 (2), 145-162, 2019-02-01
The Society of Synthetic Organic Chemistry, Japan
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Details 詳細情報について
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- CRID
- 1390001288122178816
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- NII Article ID
- 130007595435
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- NII Book ID
- AN0024521X
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- ISSN
- 18836526
- 00379980
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- NDL BIB ID
- 029510744
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed