Applications of Tympanic Membrane Regeneration for Middle Ear Surgery

DOI
  • Kanemaru Shin-ichi
    Department of Otolaryngology, Head and Neck Surgery, The Tazuke Kofukai Medical Research Institute, Kitano Hospital Department of Otolaryngology, Institute of Biomedical Research and Innovation Hospital Translational Research Informatics Center, Foundation for Biomedical Research and Innovation
  • Kanai Rie
    Department of Otolaryngology, Head and Neck Surgery, The Tazuke Kofukai Medical Research Institute, Kitano Hospital Department of Otolaryngology, Institute of Biomedical Research and Innovation Hospital

Bibliographic Information

Other Title
  • 鼓膜再生の中耳手術への応用
  • ─低侵襲中耳手術の開発─
  • –Development of minimally invasive middle ear surgery–

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Description

<p>Tissue engineered regeneration of the tympanic membrane (TM) is a very useful and minimally invasive treatment that does not require skin incision nor the harvesting of autologous tissue. Moreover, with this treatment we can achieve optimal hearing improvement with little air-bone gap. For successful application of this treatment, however, several conditions should be met. For example, we limited the adaptation of this treatment to patients with a dry TM perforation and those in which it was easy to visualize the entire TM with a microscope.</p><p>In order to increase the number of patient candidates for this treatment, we attempted to apply this regenerative procedure to patients with wet TM perforations and/or those in which it was difficult to observe the TM perforation edge due to a narrow external auditory canal.</p><p>For patients in the former category, we repeatedly washed the tympanic cavity through the perforation using saline prior to the regenerative procedure. For patients with the latter condition, we performed this regenerative procedure with the use of an endoscope and/or after enlargement of the external auditory canal. With these procedures, we achieved 80% regenerative rates even in previously excluded patients. The combination of these new procedures for regenerative treatment of the TM reduces the need for invasive surgeries such as tympanoplasty and myringoplasty.</p>

Journal

  • Otology Japan

    Otology Japan 27 (2), 131-134, 2017

    Japan Otological Society

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