Effect of vitamin C ingestion on the vascular endothelial function exposed to transient passive smoking

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  • Azuma Ayako
    Center for Faculty-wide General Education, Shikoku University Graduate School of Integrated Arts and Science, Tokushima University
  • Miura Hajime
    Laboratory for Applied Physiology, Faculty of Integrated Arts and Science, Tokushima University
  • Ishikawa Mizuki
    Graduate School of Integrated Arts and Science, Tokushima University

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Other Title
  • ビタミンCが一過性の受動喫煙時の動脈機能に及ぼす影響
  • ビタミン C ガ イッカセイ ノ ジュドウ キツエンジ ノ ドウミャク キノウ ニ オヨボス エイキョウ

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Abstract

<p></p><p>As well as active smoking, passive smoking is associated with a high risk of developing cardiovascular disease. The antioxidant vitamin C may inhibit the unfavorable effects of passive smoking. In this study, we investigated the effects of vitamin C ingestion on changes in the flow-mediated dilatation (FMD) at the brachial artery in patients exposed to transient passive smoking. The study participants included seven healthy adult males who were examined by high-resolution ultrasonography of the brachial artery before and after 15-minute of passive smoking. FMD was used to examine the endothelial function. Randomized crossover controlled trial, measurements were performed on two different days 120-minute after the oral administration of 1000mg of ascorbic acid (VC trial) or a placebo (P trial). Although the FMD values decreased after passive smoking in both trials, the FMD values of the VC trial were higher than those of the P trial, with significant differences between the trials observed immediately and 30-minute after passive smoking. The results of this study suggested that the ingestion of vitamin C may suppress the decrease in the vascular endothelial function caused by transient passive smoking.</p>

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