Revealing neural and circuit pathophysiology of neuropsychiatric disorders

DOI Web Site
  • Sugaya Yuki
    Department of Neurophysiology, Division of Functional Biology, Graduate School of Medicine, University of Tokyo

Bibliographic Information

Other Title
  • 神経回路の機能解析を通じた病態解明
  • シンケイ カイロ ノ キノウ カイセキ オ ツウジタ ビョウタイ カイメイ

Search this article

Abstract

To understand and explain the symptoms of neuropsychiatric disorders from the activity of neurons and the synaptic input is one of the most important goals of the research in biological psychiatry. Recent advances in technology have made it possible to manipulate and record the activity of hundreds of selective neurons in vivo. Combining these advancements with conventional electrophysiology, which still have advantages in simplicity and temporal resolution, will help to explain the circuit pathophysiology of neuropsychiatric disorders such as epilepsy. Animal models of epilepsy show similar behavioral and electrophysiological phenotypes with humans and therefore can be compared more directly in comparison to other neuropsychiatric disorders. In this article, I would like to show how new and conventional methods for neuroscience research can be combined to clarify the pathophysiology of epileptic seizures exaggerated by the decrease of endocannabinoid signaling. Extracellular field recording, current source density analysis with multiple electrodes, in vivo whole cell recording and optogenetics were used for the experiment and the pros and cons of each method are explained.

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top