Blueberry leaf polyphenols prevent body fat accumulation in mice fed high-fat

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  • Fujii Kento
    Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki
  • Ota Yuma
    Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki
  • Nishiyama Kazuo
    Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki
  • Kunitake Hisato
    Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki
  • Yamasaki Yumi
    Faculty of Regional Innovation, University of Miyazaki
  • Tari Hiroyuki
    Bizen Chemical Company Limited
  • Araki Kaori
    Bizen Chemical Company Limited
  • Arakawa Teruaki
    Bizen Chemical Company Limited
  • Yamasaki Masao
    Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki

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  • Blueberry Leaf Polyphenols Prevent Body Fat Accumulation in Mice Fed High-fat, High-sucrose Diet

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<p>Blueberry leaf is currently a popular dietary supplement. Effects of dietary blueberry leaf and its active components on body fat accumulation were examined. C57BL/6J mice were fed high-fat, high-sucrose diet with or without 3% blueberry leaf extract (BLEx) or 3% concentrated-polyphenolic BLEx (CP BLEx) for 8 weeks. Compared to mice fed a high-fat, high-sucrose diet without blueberry leaf, BLEx and CP BLEx significantly reduced body weight and adipose tissue weight gain. Adipocytes were also smaller and and liver lipid accumulatioin was significantly inhibited in mice fed either BLEx or CP BLEx. These effects tended to be more pronounced in mice fed CP BLEx compared to in mice fed BLEx. Together, results suggest that blueberry leaf inhibits body fat accumulation typically observed in mice fed a high-fat, high-sucrose diet, and that inhibition is attributable to polyphenolic components in leaf extracts.</p>

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