Mature T- and NK-cell lymphomas

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Other Title
  • 成熟T/NK細胞性リンパ腫
  • セイジュク T/NK サイボウセイ リンパシュ
  • —deepening of genomic medicine and future prospects—

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Description

<p>Mature T- and NK-cell neoplasms are a heterogeneous hematological malignancy. The current treatment of mature T- and NK-cell lymphoma depends on combination chemotherapy with or without auto/allogeneic hematopoietic stem cell transplantation. Recent comprehensive, integrated genetic analyses have revealed distinct genetic and molecular subgroups, which are related to different therapeutic responses. Thus, the genetic landscape of mature T- and NK-cell neoplasms is essential for the development of novel treatment modalities and offers opportunities for individualized therapy. This review aims to discuss the recent progress regarding genetic and molecular analyses of mature T- and NK-cell neoplasms toward stratified therapy.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 60 (5), 441-446, 2019

    The Japanese Society of Hematology

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