太さの異なるナノファイバーへのタンパク質吸着特性

DOI Web Site Web Site 参考文献1件
  • 坂元 博昭
    国立大学法人 福井大学大学院工学研究科 繊維先端工学専攻
  • 目細 太一
    国立大学法人 福井大学工学部材料開発工学科
  • 末 信一朗
    国立大学法人 福井大学大学院工学研究科 繊維先端工学専攻

書誌事項

タイトル別名
  • Protein Adsorption Behavior onto Polyurethane Nanofiber with Different Diameter
  • フトサ ノ コトナル ナノファイバー エ ノ タンパクシツ キュウチャク トクセイ

この論文をさがす

抄録

<p>Conformation and activity control of proteins adsorbed on certain material surfaces enables the development of numerous high-performance applications. Previously, we examined the relationship between the diameter (surface shape) of polyurethane (PU) nanofibers and the conformation/activity of adsorbed protein. Proteins adsorbed on thick nanofibers (diameter: 950 nm) showed decreased activity due to large conformational changes, whereas those adsorbed on thin nanofibers (diameter: 480 nm) retained a close-to-natural shape and thus showed relatively high activity, confirming that the shape of PU nanofiber surface affects the conformation and activity of proteins adsorbed thereon. In this study, in order to prove this hypothesis, the adsorption strength of the adsorbed protein onto the polyurethane nanofiber was evaluated. As a result, it was confirmed that proteins adsorbed on thick nanofibers have higher adsorption strength than thin nanofibers. These results suggested that the thickness of the nanofibers determines the adsorption area between molecule and nanofiber surface, and affects the structure and activity of the adsorbed protein.</p>

収録刊行物

参考文献 (1)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ