Swelling of Eyeball Accompanied with Lens Luxation in Four Mongolian Gerbils

DOI
  • OGAWA Tatsuya
    Gotemba Laboratory, BoZo Research Center Inc.
  • OKADA Yumiko
    Division of Biomedical Food Research, National Institute of Health Sciences
  • KUSE Hiroshi
    Gotemba Laboratory, BoZo Research Center Inc.
  • KEMI Masayuki
    Tsukuba Research Institute, BoZo Research Center Inc.
  • SUZUKI Hodaka
    Division of Biomedical Food Research, National Institute of Health Sciences

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Other Title
  • 水晶体脱臼を伴う眼球腫大のスナネズミ4症例

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Abstract

<p>The Mongolian gerbils (Meriones unguiculatus) are one of the experimental animal models which were established in Japan1). Abnormally larger eyes were found unilaterally, either right or left, in five out of 686 post-weaning Mongolian gerbils, in our breeding colony, which was started from four pairs of MGW inbred albino strain gerbils and maintained for around one year. Ophthalmological and histopathological examinations were conducted on the eyeballs from four out of these five animals. The affected eyeballs were swollen and showed anterior synechia in all four cases. The lens with opacity of one animal moved freely in the intraocular space depending on the direction of animal's head and those of the other three animals were unevenly located near the Ciliary body or posterior position, and these ocular lesions were diagnosed as lens luxation. Histopathological examination revealed imperfect formation of the ciliary body and zonula ciliaris (Zinn's zonule), suggesting lens luxation due to abnormal formation of the zonula ciliaris that plays a role as a supporting system of the lens. However, these ocular lesions were accompanied by phenomena indicating elevated intraocular pressure, such as enlarged eyeball, edematous cornea, thinning of the cornea and retina, atrophy of the optic nerve, and cupping of the optic disk, and glaucoma was suggested. Thus, such abnormal zonula ciliaris (and its consequent lens luxation) might have occurred following glaucoma. It is suggested that genetic background might be involved in these ocular lesions because all four cases were occurred in the colony, although the prevalence was low.</p>

Journal

  • Animal Eye Research

    Animal Eye Research 34 (0), 21-27, 2015

    Japanese Society of Comparative and Veterinary Ophthalmology

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