Whole-brain activity mapping at single-cell resolution

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  • Kasai Atsushi
    Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
  • Seiriki Kaoru
    Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University Institute for Transdisciplinary Graduate Degree Programs, Osaka University
  • Hashimoto Hitoshi
    Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University Molecular Research Center for Children’s Mental Development, United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui Institute for Datability Science, Osaka University Open and Transdisciplinary Research Initiatives, Osaka University

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  • 脳機能の解明に向けた全脳神経活動マッピング
  • ノウ キノウ ノ カイメイ ニ ムケタ ゼン ノウ シンケイ カツドウ マッピング

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Abstract

<p>The neuronal activity forms the basis of functional circuits and brain functions. To understand how the brain operates, recording of neural activity at micro-, meso-, and macro-scales is required. Recently, improved optical microscopic technology helps us to develop a whole-brain imaging system at a single-cell resolution. The combination of a whole-brain imaging system and a reporter system of neuronal activation enables a whole-brain mapping of neuronal activity. In this review, we first describe the high-speed and scalable whole-brain imaging system including our recently developed system, named FAST, and then present the instances of whole-brain mapping of neuronal activity and its analytical methods.</p>

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