Prospects for bovine production disease control based on the mucosal immunity and innate immune system : From the respiratory mucosal defense and alveolar macrophage dynamics

Ishikawa S., Ohtsuka H.

doi:10.4190/jjlac.7.217

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Other Title

粘膜免疫と自然免疫システムを応用した牛の生産病コントロールへの展望～牛の呼吸器粘膜防御と肺胞マクロファージの動態から～
ネンマクメンエキトシゼンメンエキシステムオオウヨウシタウシノセイサンビョウコントロールエノテンボウ : ウシノコキュウキネンマクボウギョトハイホウマクロファージノドウタイカラ

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Abstract

<p>　Respiratory, gastrointestinal, urological and reproductive diseases account for a large part of bovine production diseases. All of these diseases develop on the mucosal surfaces of the respective organs. The mucosa-associated lymphoid tissue（MALT）is a secondary lymphoid tissue providing a specific immune system in the mucosa, and understanding the bovine MALT is an important part of the efforts toward the control of bovine production diseases.</p><p>　In recent years, research on the innate immune system, which provides early immunity in infection, has progressed rapidly, and pathogen recognition mechanisms and the diversity of innate immunity cells have been elucidated. We now know that innate immune cells in the mucosal immune system have a unique nature and that the interactions between the mucosal immune system and innate immune system are indispensable. The concept of protective immunity against infection in cattle, however, is still discussed from the perspective of the acquired immune system primarily based on antibody titers in blood. We will discuss how we can control bovine production diseases using the mucosal immunity and innate immunity.</p>

Journal

Japanese Journal of Large Animal Clinics

Japanese Journal of Large Animal Clinics 7 (Supple), 217-224, 2017-03-31

Japanese Society of Large Animal Clinics / Large Animal Clinic Research Association

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