Shorter Leukocyte Telomere Length Is Associated With Atrial Remodeling and Predicts Recurrence in Younger Patients With Paroxysmal Atrial Fibrillation After Radiofrequency Ablation
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- Pan Kuo-Li
- Division of Cardiology, Chang Gung Memorial Hospital School of Traditional Chinese Medicine, College of Medicine, Chang Gung University
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- Hsiao Ya-Wen
- Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital
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- Lin Yenn-Jiang
- Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital School of Medicine, Faculty of Medicine, National Yang-Ming University
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- Lo Li-Wei
- Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital School of Medicine, Faculty of Medicine, National Yang-Ming University
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- Hu Yu-Feng
- Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital School of Medicine, Faculty of Medicine, National Yang-Ming University
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- Chung Fa-Po
- Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital School of Medicine, Faculty of Medicine, National Yang-Ming University
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- Tsai Yung-Nan
- Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital School of Medicine, Faculty of Medicine, National Yang-Ming University
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- Chao Tze-Fan
- Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital School of Medicine, Faculty of Medicine, National Yang-Ming University
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- Liao Jo-Nan
- Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital School of Medicine, Faculty of Medicine, National Yang-Ming University
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- Lin Chin-Yu
- Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital School of Medicine, Faculty of Medicine, National Yang-Ming University
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- Jhuo Shih-Jie
- Division of Cardiology, Kaohsiung Medical University Hospital
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- Lin Chung-Hsing
- Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University
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- Suresh Allamsetty
- Department of Cardiology, Nizam’s Institute of Medical Sciences
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- Walia Rohit
- Division of Cardiology, Medanta Heart Institute, Medanta The Medicity
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- Te Abigail Louise D.
- Heart Institute, St. Luke’s Medical Center
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- Yamada Shinya
- Department of Cardiology and Hematology, Fukushima Medical University
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- Chang Yao-Ting
- Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital School of Medicine, Faculty of Medicine, National Yang-Ming University
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- Chang Shih-Lin
- Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital School of Medicine, Faculty of Medicine, National Yang-Ming University
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- Chen Shih-Ann
- Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital School of Medicine, Faculty of Medicine, National Yang-Ming University
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Abstract
<p>Background:Telomere length is a biologic aging marker. This study investigated leukocyte telomere length (LTL) as a new biomarker to predict recurrence after paroxysmal atrial fibrillation (PAF) ablation.</p><p>Methods and Results:A total of 131 participants (26 healthy individuals and 105 symptomatic PAF patients) were enrolled. PAF patients (54.1±10.8 years) who received catheter ablation therapy were divided into 2 groups: recurrent AF (n=25) and no recurrent AF after catheter ablation (n=80). Peripheral blood mononuclear cells were collected from all subjects to measure LTL. Under 50 years old, LTL in healthy individuals (n=17) was longer than in PAF patients (n=31; 7.34±0.58 kbp vs. 6.44±0.91 kbp, P=0.01). In PAF patients, LTL was positively correlated with left atrial bipolar voltage (R=0.497, P<0.001), and negatively correlated with biatrial scar area (R=−0.570, P<0.001) and left atrial diameter (R=−0.214, P=0.028). LTL was shorter in the patients with recurrent AF than in those without recurrent AF after catheter ablation (5.68±0.82 kbp vs. 6.66±0.71 kbp; P<0.001). On receiver operating characteristic curve analysis, LTL cut-off <6.14 kbp had a specificity of 0.68 and sensitivity of 0.79 to predict recurrent AF after catheter ablation.</p><p>Conclusions:Young PAF patients (≤50 years) had shorter LTL. Shorter LTL was associated with a degenerative atrial substrate and recurrence after catheter ablation in younger PAF patients.</p>
Journal
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- Circulation Journal
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Circulation Journal 83 (7), 1449-1455, 2019-06-25
The Japanese Circulation Society
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Details 詳細情報について
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- CRID
- 1390001288147258752
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- NII Article ID
- 130007666961
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- NII Book ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- NDL BIB ID
- 029762221
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- PubMed
- 31118363
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed