Primary screening of Japanese women for cervical cancer

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  • わが国における子宮頸がんの一次スクリーニング法

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Abstract

<p>Objective : This is a report of primary screening of Japanese women for cervical cancer, the screening method involving a combination of the HPV status and cytological results ; we also evaluated the usefulness of MPM test as a primary screening method for cervical cancer.</p><p>Study Design : The MPM test simultaneously amplifies a total 13 high risk-HPV types by multiplex PCR in a single reaction tube, which are separated by electrophoresis. Seven high risk-HPV, types 16, 18, 31, 33, 35, 52, 58 are examined individually (Sup hrHPV) and the remaining six high risk-HPV are detected together as one (other hrHPV).</p><p>Results : The HPV-based screening detected a higher number of ≧CIN3 cases than conventional cytology. The following genotypes were associated with the risk of progression to ≧CIN3 in this small study HPV16, 52, 33, 18, 58. In 5 previous reports based on studies of Japanese women, ≧CIN3 was reported to be most commonly associated HPV genotypes 16, 52, 58, 31, 33, 18 and 35, (ratios of S-hrHPV to total-hrHPV, 94%). On the other hand, in Japanese women with low-grade cervical lesions and NILM, the ratios of S-hrHPV to total-hrHPV was only about 67-69%.</p><p>Conclusion : Introduction of “sup hrHPV” for primary screening reduces overdiagnosis. The findings lend support to a screening intervals of 3 years for Japanese women with a negative result of NILM for HPV, similar to the case in the US.</p>

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