Cerebral venous sinus ihrombosis with ulcerative colitis and antiphospholipid antibody syndrome: a case report

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  • Ueki Yasuhito
    Department of Neurosurgery, Juntendo University, Nerima hospital
  • Abe Eiji
    Department of Neurosurgery, Juntendo University, Nerima hospital
  • Kudo Kentaro
    Department of Neurosurgery, Juntendo University, Nerima hospital
  • Tokugawa Joji
    Department of Neurosurgery, Juntendo University, Nerima hospital
  • Mitsuhashi Takashi
    Department of Neurosurgery, Juntendo University, Nerima hospital
  • Hishii Makoto
    Department of Neurosurgery, Juntendo University, Nerima hospital

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  • 潰瘍性大腸炎と抗リン脂質抗体症候群を併発し，脳静脈洞血栓症を発症した1 例

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Abstract

<p>A 41-year-old man with ulcerative colitis and antiphospholipid antibody syndrome as the underlying disease was taken the direct oral anticoagulant for a history of repetitive deep venous thrombosis, which was temporarily stopped because of the recent bloody stool. As the pulmonary embolism was occurred immediately after the discontinuation of the anticoagulant, the patient was hospitalized and the intravenous heparin administration was started. Headache and the left hemiparesis were suddenly appeared on the day six of the hospitalization. Magnetic resonance images revealed a cerebral infarction on the right parietal lobe and the thrombus in the sagittal sinus and the transverse sinus. The patient was diagnosed with cerebral venous sinus thrombosis. On the following day, decompressive craniectomy was performed for acute brain swelling from the expanded bilateral cerebral hemorrhagic infarction. Unfortunately, the patient was died on the day nine of the hospitalization. Eventhough either ulcerative colitis or antiphospholipid antibody syndrome can be a risk of thrombosis, report of thrombosis concurrent with the two diseases is extremely rare and only four cases have been reported in the literature. We reported another rare case with literature review.</p>

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