Antibacterial Activity of 1,2-Alkanediol against Staphylococcus aureus and Staphylococcus epidermidis

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  • Okukawa Minako
    Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University
  • Watanabe Takamasa
    Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University
  • Miura Maki
    Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University
  • Konno Hiroyuki
    Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University
  • Yano Shigekazu
    Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University
  • Nonomura Yoshimune
    Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University

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  • Antibacterial Activity of 1,2-Alkanediol against <i>Staphylococcus aureus</i> and <i>Staph</i><i>ylococcus epidermidis</i>

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<p>1,2-Alkanediol exhibits antibacterial activity against several bacteria and yeast. However, few studies have reported antimicrobial tests on skin microbiome. Bacterial microbiome on the skin surface include Staphylococcus aureus (S. aureus), which causes rough skin and inflammation in atopic dermatitis and Staphylococcus epidermidis (S. epidermidis), which enhances innate immunity. In this study, the minimal inhibitory concentration (MIC) was evaluated for 1,2-alkanediol comprising 4–12 carbon atoms against S. aureus and S. epidermidis. 1,2-Alkanediol comprising 6–12 carbon atoms exhibited antimicrobial activity against both species of Staphylococcus. The antibacterial activity depended on the alkyl chain length. In addition, the minimum bactericidal concentration (MBC) on agar was evaluated for 1,2-alkanediol comprising 6–12 carbon atoms. 1,2-Octanediol and 1,2-decanediol exhibited significant bactericidal activity.</p>

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