Characterization and differentiation of positional isomers of fluoro-fentanyl analogs by a combination of instrumental analyses
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- Kanamori Tatsuyuki
- National Research Institute of Police Science
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- Iwata Yuko T.
- National Research Institute of Police Science
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- Segawa Hiroki
- National Research Institute of Police Science
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- Yamamuro Tadashi
- National Research Institute of Police Science
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- Kuwayama Kenji
- National Research Institute of Police Science
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- Tsujikawa Kenji
- National Research Institute of Police Science
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- Inoue Hiroyuki
- National Research Institute of Police Science
Bibliographic Information
- Other Title
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- 各種機器分析によるフルオロ-フェンタニル類の位置異性体識別
- カクシュ キキ ブンセキ ニ ヨル フルオロ-フェンタニルルイ ノ イチ イセイタイ シキベツ
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Description
<p> The isomers of fluoro-butyrylfentanyl, fluoro-isobutyrylfentanyl, and fluoro-methoxyacetylfentanyl, in which the position of fluorine on the N-phenyl ring varies, were synthesized, characterized, and differentiated by infrared (IR) spectroscopy, liquid chromatography/mass spectrometry (LC/MS), and gas chromatography/mass spectrometry (GC/MS). The isomers could be clearly differentiated by their IR spectra. In the LC/MS chromatograms, the separation of the fluoro-butyrylfentanyl and fluoro-isobutyrylfentanyl isomers was insufficient. However, in the GC/MS extracted ion chromatograms, all compounds were completely separated. The LC/MS and GC/MS mass spectra of the isomers were similar, demonstrating that it is difficult to distinguish the positional isomers of fluorinated fentanyl analogs by their mass spectra.</p>
Journal
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- Japanese Journal of Forensic Science and Technology
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Japanese Journal of Forensic Science and Technology 24 (2), 123-133, 2019
Japanese Association of Forensic Science and Technology
