High-Pressure Microscopy for Controlling Microtubule Dynamics

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  • 高圧力顕微鏡法による微小管のダイナミックコントロール
  • コウアツリョク ケンビキョウホウ ニ ヨル ビショウカン ノ ダイナミックコントロール

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Abstract

<p>Protein molecules assemble to form molecular machineries in living cells. Their biologically important reactions occur with association of water molecules that surround the protein molecules. Application of pressure is a powerful method for modulating intermolecular interactions between protein and water molecules. We have developed high-pressure microscopy for controlling the structure and function of molecular machinery working in living cells. In this review, we describe a short summary of our high-pressure microscope. The developed system allows us to visualize the polymerization and de-polymerization dynamics of microtubules at high-pressure.</p>

Journal

  • KENBIKYO

    KENBIKYO 51 (2), 118-121, 2016-08-30

    The Japanese Society of Microscopy

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