Case Report: Stiff Person Syndrome with Thymoma

Sonokawa Takumi, Shizukawa Hirohiko, Ichihara Shin, Muraoka Shunji, Usuda Jitsuo, Tanaka Koichi

doi:10.2482/haigan.59.360

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<p>Background. Stiff person syndrome is a rare neurological syndrome characterized by fluctuating muscle rigidity and painful spasms. About 5-8% of stiff person syndrome cases are associated with malignant tumors, and the symptoms can manifest as a paraneoplastic disorder. Case. We herein report a 68-year-old man who was referred to our hospital with a chief complaint of gait disturbance due to painful muscle rigidity in both legs. Examinations of the head and spine showed no abnormalities. However, on chest computed tomography, an anterior mediastinal tumor was seen, and blood tests showed a high titer of anti-glutamic acid decarboxylase antibody. These findings suggested that his symptoms could be attributed to paraneoplastic neurological syndrome associated with the mediastinal tumor. Furthermore, characteristic symptoms and laboratory findings also indicated stiff person syndrome. These symptoms were not affected by initial treatment with steroids, but they were improved by benzodiazepine and baclofen treatment. The pathological diagnosis after radical thymectomy was type B2 thymoma. The patient's postoperative course was uneventful. His medications were decreased, and his symptoms gradually improved. Conclusion. Thymectomy might offer symptomatic relief for stiff person syndrome associated with thymoma.</p>

収録刊行物

肺癌

肺癌 59 (4), 360-365, 2019-08-20

特定非営利活動法人日本肺癌学会

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CRID: 1390001288162304256

NII論文ID: 130007696879

DOI: 10.2482/haigan.59.360

ISSN: 13489992; 03869628

Web Site: https://www.jstage.jst.go.jp/article/haigan/59/4/59_360/_pdf; https://search.jamas.or.jp/link/ui/2020222485

本文言語コード: en

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