Cupid and Psyche system for the diagnosis and treatment of advanced cancer
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- SUGIYAMA Akira
- Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo Isotope Science Center, The University of Tokyo
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- KAWAMURA Takeshi
- Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo Isotope Science Center, The University of Tokyo
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- TANAKA Toshiya
- Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
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- DOI Hirofumi
- Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
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- YAMASHITA Takefumi
- Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
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- SHINODA Keiko
- Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
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- FUJITANI Hideaki
- Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
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- YAMATSUGU Kenzo
- Graduate School of Pharmaceutical Sciences, The University of Tokyo
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- SHIMIZU Yohei
- Graduate School of Pharmaceutical Sciences, The University of Tokyo
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- TATSUMI Toshifumi
- Graduate School of Pharmaceutical Sciences, The University of Tokyo
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- TAKAHASHI Kazuki
- Graduate School of Pharmaceutical Sciences, The University of Tokyo
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- KANAI Motomu
- Graduate School of Pharmaceutical Sciences, The University of Tokyo
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- MIZOHATA Eiichi
- Division of Applied Chemistry, Graduate School of Engineering, Osaka University
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- KAWATO Tatsuya
- Division of Applied Chemistry, Graduate School of Engineering, Osaka University
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- DOI Takefumi
- Graduate School and School of Pharmaceutical Sciences, Osaka University
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- INOUE Tsuyoshi
- Graduate School and School of Pharmaceutical Sciences, Osaka University
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- KODAMA Tatsuhiko
- Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
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説明
<p>In advanced cancer patients, malignant cells invade and disseminate within normal cells and develop resistance to therapy with additional genetic mutations, which makes radical cure very difficult. Precision medicine against advanced cancer is hampered by the lack of systems aimed at multiple target molecules within multiple loci. Here, we report the development of a versatile diagnostic and therapeutic system for advanced cancer, named the Cupid and Psyche system. Based on the strong non-covalent interaction of streptavidin and biotin, a low immunogenic mutated streptavidin, Cupid, and a modified artificial biotin, Psyche, have been designed. Cupid can be fused with various single-chain variable fragment antibodies and forms tetramer to recognize cancer cells precisely. Psyche can be conjugated to a wide range of diagnostic and therapeutic agents against malignant cells. The Cupid and Psyche system can be used in pre-targeting therapy as well as photo-immunotherapy effectively in animal models supporting the concept of a system for precision medicine for multiple targets within multiple loci.</p>
収録刊行物
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- Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences
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Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences 95 (10), 602-611, 2019-12-11
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詳細情報 詳細情報について
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- CRID
- 1390002184850125056
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- NII論文ID
- 130007760701
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- NII書誌ID
- AA00785485
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- ISSN
- 13492896
- 03862208
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- NDL書誌ID
- 030147534
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- PubMed
- 31827018
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可