Cupid and Psyche system for the diagnosis and treatment of advanced cancer

DOI Web Site Web Site PubMed 被引用文献4件 参考文献5件
  • SUGIYAMA Akira
    Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo Isotope Science Center, The University of Tokyo
  • KAWAMURA Takeshi
    Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo Isotope Science Center, The University of Tokyo
  • TANAKA Toshiya
    Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
  • DOI Hirofumi
    Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
  • YAMASHITA Takefumi
    Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
  • SHINODA Keiko
    Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
  • FUJITANI Hideaki
    Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
  • YAMATSUGU Kenzo
    Graduate School of Pharmaceutical Sciences, The University of Tokyo
  • SHIMIZU Yohei
    Graduate School of Pharmaceutical Sciences, The University of Tokyo
  • TATSUMI Toshifumi
    Graduate School of Pharmaceutical Sciences, The University of Tokyo
  • TAKAHASHI Kazuki
    Graduate School of Pharmaceutical Sciences, The University of Tokyo
  • KANAI Motomu
    Graduate School of Pharmaceutical Sciences, The University of Tokyo
  • MIZOHATA Eiichi
    Division of Applied Chemistry, Graduate School of Engineering, Osaka University
  • KAWATO Tatsuya
    Division of Applied Chemistry, Graduate School of Engineering, Osaka University
  • DOI Takefumi
    Graduate School and School of Pharmaceutical Sciences, Osaka University
  • INOUE Tsuyoshi
    Graduate School and School of Pharmaceutical Sciences, Osaka University
  • KODAMA Tatsuhiko
    Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo

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<p>In advanced cancer patients, malignant cells invade and disseminate within normal cells and develop resistance to therapy with additional genetic mutations, which makes radical cure very difficult. Precision medicine against advanced cancer is hampered by the lack of systems aimed at multiple target molecules within multiple loci. Here, we report the development of a versatile diagnostic and therapeutic system for advanced cancer, named the Cupid and Psyche system. Based on the strong non-covalent interaction of streptavidin and biotin, a low immunogenic mutated streptavidin, Cupid, and a modified artificial biotin, Psyche, have been designed. Cupid can be fused with various single-chain variable fragment antibodies and forms tetramer to recognize cancer cells precisely. Psyche can be conjugated to a wide range of diagnostic and therapeutic agents against malignant cells. The Cupid and Psyche system can be used in pre-targeting therapy as well as photo-immunotherapy effectively in animal models supporting the concept of a system for precision medicine for multiple targets within multiple loci.</p>

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