変形性膝関節症におけるメカニカルストレス研究と間葉系幹細胞治療後の再生リハビリテーション

DOI
  • 飯島 弘貴
    慶應義塾大学 理工学部 システムデザイン工学科 日本学術振興会特別研究員 京都大学大学院 医学研究科 人間健康科学系専攻理学療法学講座

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  • Mechanical stress research and regenerative rehabilitation after mesenchymal stem cell treatment in people with knee osteoarthritis

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<p>Mesenchymal stem cells (MSCs) have emerged as a cell type with great potential for cell-based articular cartilage repair in patients with knee osteoarthritis (OA). However, meta-analysis of clinical trials of the MSC treatment revealed that current evidence about articular cartilage regeneration and objectively measured functional improvement in people with knee OA was inconclusive. Research for regenerative rehabilitation, a recently emerged interdisciplinary field, could contribute to establish effective cell-based therapy that maximizes cartilage regeneration and functional improvement in people with knee OA. We herein summarize our cross-disciplinary approaches toward establishing effective regenerative rehabilitation in MSC-based treatment for people with knee OA. This review would serve as the foundation for future studies investigating the effects of rehabilitative approaches in regenerative medicine that lead clinical success of cell-based treatment.</p>

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