Kampo and Cancer Immunity in the Era of Immune Checkpoint Inhibitors

  • SHIMADA Mitsuo
    Department of Surgery, Tokushima University Graduate School of Biomedical Sciences
  • MORINE Yuji
    Department of Surgery, Tokushima University Graduate School of Biomedical Sciences
  • IKEMOTO Tetsuya
    Department of Surgery, Tokushima University Graduate School of Biomedical Sciences
  • YOSHIKAWA Kozo
    Department of Surgery, Tokushima University Graduate School of Biomedical Sciences
  • TAKASU Chie
    Department of Surgery, Tokushima University Graduate School of Biomedical Sciences

Bibliographic Information

Other Title
  • 免疫チェックポイント時代における漢方とがん免疫
  • メンエキ チェックポイント ジダイ ニ オケル カンポウ ト ガン メンエキ

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Description

<p>Kampo medicine is well known to play an important role in cancer therapy, especially as a supportive therapy. We literally investigated the significance of Kampo medicine on antitumor effect including our data in the era that cancer immunotherapy using immune checkpoint inhibitors is a main stream. Up to now, many reports have been published regarding the mechanism of Kampo medicine on augmentation of immunity, particularly innate immunity. Regarding the effect of Kampo medicine on cancel of immune suppression by cancer, a few reports have been published including our data that juzentaihoto reduced regulatory T cell ratio in advanced pancreas cancer patients. Interestingly, a certain kind of Kampo medicine has possibility to induce immune tolerance in murine cardiac transplant model through increased regulatory T cells, and to suppress intestinal inflammation by anticancer drug by functioning immune checkpoint (PD-1). We hope that Kampo medicine would be proved to possibly regulate immune function from the viewpoint of immune checkpoint in the near future.</p>

Journal

  • Kampo Medicine

    Kampo Medicine 70 (2), 162-166, 2019

    The Japan Society for Oriental Medicine

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