Central regulation of plasma catecholamine release and secretion induced by stress

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  • Okada Shoshiro
    Department of Pharmacology, Graduate School of Medicine, Aichi Medical University

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  • ストレスによる血中カテコールアミン遊離・分泌の中枢性調節機構

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Abstract

<p>It is well known that stress not only activates the hypothalamic-pituitary-adrenal axis, but also sympatho-adrenomedullary outflow. Activation of these systems leads to secretion of cortisol (corticosterone) or release/secretion of catecholamines. However, the precise mechanisms underlying these phenomena are still unresolved. We previously investigated the mechanisms of central activation of sympatho-adrenomedullary outflow with regard to prostanoid (prostaglandin E2 and thromboxane A2) and adrenoceptor (α-and β-adrenoceptors) in the brain using anesthetized rats. In this paper, we outline the regulatory mechanisms of plasma catecholamine levels in the paraventricular nucleus of the hypothalamus, the major center for regulation of sympathetic function and stress responses, based on our previous reports.</p>

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