Prefrontal‐enriched SLIT1 expression in primate cortex and its alteration during cortical development

  • Sasaki Tetsuya
    Division of Brain Biology, National Institute for Basic Biology (NIBB) Department of Anatomy and Neuroscience, Faculty of Medicine, University of Tsukuba
  • Komatsu Yusuke
    Division of Brain Biology, National Institute for Basic Biology (NIBB) ACD Inc.
  • Yamamori Tetsuo
    Division of Brain Biology, National Institute for Basic Biology (NIBB) Laboratory for Molecular Analysis of Higher Brain Function, RIKEN Center for Brain Science

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  • 霊長類前頭前皮質に局在したSLIT1の発現と生後発達変化
  • レイチョウルイ ゼントウ ゼン ヒシツ ニ キョクザイシタ SLIT1 ノ ハツゲン ト セイゴ ハッタツ ヘンカ

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Abstract

To study molecular basis for specialization of cortical architectures in primates, we have searched for genes differentially expressed among neocortical areas of macaque monkeys by restriction landmark cDNA screening (RLCS) . In the present study, we found that SLIT1, a member of axon guidance molecules, is enriched in the prefrontal cortex (PFC) . In situ hybridization analysis revealed that SLIT1 mRNA is mainly distributed in the middle layers of most cortical areas, highest in the PFC but fainter in primary sensory areas, lowest in V1. Other SLITs (SLIT2 and SLIT3) mRNAs exhibited modest specificity in the PFC, while the receptor, Roundabouts (ROBO1 and ROBO2) , mRNAs were widely distributed in the cortex. From late fetal to early postnatal days, SLIT1 mRNA was abundantly expressed in layers IV and VI throughout neocortex (except for V1) . The downregulation of the expression occurs initially in the sensory areas and follows in the association areas around postnatal days 60, and the prefrontal‐enriched pattern was established due to by the area‐and laminar‐specific reduced expression. These results suggest that the roles of SLIT1 are altered from the developmental to matured cortex to maintenance the prefrontal circuits in primates.

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