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- 櫻井 栄一
- 徳島文理大学薬学部薬剤学教室
書誌事項
- タイトル別名
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- Elucidation of New Function in Endothelial Cells for Efficient Delivery Strategy of Drug to Tissues
- ヤクブツ ノ ソシキ エ ノ コウリツテキ ナ デリバリー センリャク コウチク オ メザシタ ケッカン ナイヒ サイボウ ノ アラタ ナ キノウ タンサク ト カイメイ
この論文をさがす
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<p>The author has described two new functions of endothelial cells for efficient delivery of drugs to tissues. First, it was indicated that tight junction (TJ)-associated protein, claudin-1, exerts potent paracellular barrier function in cultured mouse lung microvascular endothelial cells (LMECs). This barrier was instantly and reversibly opened by reduction of TJ proteins expression via histamine H1 and H2 receptors. Histamine was biosynthesized by l-histidine decarboxylase from uptaken l-histidine, and biotransformed by type B of monoamine oxidase, suggesting that histamine concentration is controlled in rat brain MECs (BMECs) and LMECs. Moreover, uptake of l-histidine into BMECs and LMECs markedly increased with addition of ZnSO4. Second, it was suggested that drug-metabolizing enzymes such as CYP and flavin-containing monooxygenase exist in vascular endothelial cells exposed to blood and to aerobic conditions. These cells have the same ability to metabolize drugs as hepatocytes, demonstrating that vascular endothelial cells are a metabolic barrier against tissue transfer of drugs. From these results, it was suggested that reversible opening of TJ and selective inhibition of drug metabolism in vascular endothelial cells may be efficient delivery strategies of drugs to tissues. Finally, I hope that this research will lead to development of new drugs and possible re-evaluation of discontinued drugs.</p>
収録刊行物
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- 薬学雑誌
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薬学雑誌 140 (1), 51-62, 2020-01-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390002184860559232
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- NII論文ID
- 130007778760
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 030194920
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- PubMed
- 31902886
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可