書誌事項
- タイトル別名
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- Free-fibula transplantation for medication-related osteonecrosis of the jaw in a patient treated with sunitinib and bisphosphonate : a case report
- スニチニブ ・ ビスフォスフォネート セイザイ トウヨ カンジャ ニ ショウジタ ヤクザイ カンレン ガッコツ エシ ニ タイシ ユウリ ヒコツ イショク オ オコナッタ 1レイ
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説明
<p>Osteonecrosis of the jaw is a problematic side effect of bisphosphonates or angiogenesis inhibitors. Reports on surgical therapy for medication-related osteonecrosis of the jaw (MRONJ) have recently been published. However, surgical treatment of MRONJ is often difficult for patients undergoing cancer treatment who have poor general status. Oral ingestion becomes difficult, and the quality of life (QOL) declines in patients with progressive MRONJ. We describe a patient with renal cancer who had deteriorated general status due to MRONJ and was treated by mandibular resection and immediate reconstruction. A 75-year-old man treated with bisphosphonate and sunitinib for renal cancer presented with exposed mandibular bone, renal hypofunction, and hyperkalemia due to frequent use of an analgesic. We removed the sequestrum, which allowed oral ingestion and improved his general status. Then, mandibular resection and immediate reconstruction with a free-fibula flap were performed to prevent pathological fractures. However, sunitinib seemed to cause delayed wound healing. Given the cessation period of angiogenesis inhibitors and the amount of time required for wound healing, this surgical approach to MRONJ seemed useful for maintaining the QOL of this patient with renal cancer.</p>
収録刊行物
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- 日本口腔外科学会雑誌
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日本口腔外科学会雑誌 65 (11), 757-762, 2019-11-20
社団法人 日本口腔外科学会
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詳細情報 詳細情報について
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- CRID
- 1390002184864606592
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- NII論文ID
- 130007787470
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- NII書誌ID
- AN00189163
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- ISSN
- 21861579
- 00215163
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- NDL書誌ID
- 030100440
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可