スニチニブ・ビスフォスフォネート製剤投与患者に生じた薬剤関連顎骨壊死に対し遊離腓骨移植を行った1例

DOI Web Site Web Site 参考文献11件
  • 和田 麻友美
    社会医療法人北斗北斗病院歯科口腔外科 北海道大学大学院歯学研究院口腔病態学講座口腔診断内科学教室
  • 牧野 修治郎
    社会医療法人北斗北斗病院歯科口腔外科
  • 高野 昌士
    社会医療法人北斗北斗病院歯科口腔外科
  • 佐藤 健彦
    社会医療法人北斗北斗病院歯科口腔外科
  • 北川 善政
    北海道大学大学院歯学研究院口腔病態学講座口腔診断内科学教室

書誌事項

タイトル別名
  • Free-fibula transplantation for medication-related osteonecrosis of the jaw in a patient treated with sunitinib and bisphosphonate : a case report
  • スニチニブ ・ ビスフォスフォネート セイザイ トウヨ カンジャ ニ ショウジタ ヤクザイ カンレン ガッコツ エシ ニ タイシ ユウリ ヒコツ イショク オ オコナッタ 1レイ

この論文をさがす

抄録

<p>Osteonecrosis of the jaw is a problematic side effect of bisphosphonates or angiogenesis inhibitors. Reports on surgical therapy for medication-related osteonecrosis of the jaw (MRONJ) have recently been published. However, surgical treatment of MRONJ is often difficult for patients undergoing cancer treatment who have poor general status. Oral ingestion becomes difficult, and the quality of life (QOL) declines in patients with progressive MRONJ. We describe a patient with renal cancer who had deteriorated general status due to MRONJ and was treated by mandibular resection and immediate reconstruction. A 75-year-old man treated with bisphosphonate and sunitinib for renal cancer presented with exposed mandibular bone, renal hypofunction, and hyperkalemia due to frequent use of an analgesic. We removed the sequestrum, which allowed oral ingestion and improved his general status. Then, mandibular resection and immediate reconstruction with a free-fibula flap were performed to prevent pathological fractures. However, sunitinib seemed to cause delayed wound healing. Given the cessation period of angiogenesis inhibitors and the amount of time required for wound healing, this surgical approach to MRONJ seemed useful for maintaining the QOL of this patient with renal cancer.</p>

収録刊行物

参考文献 (11)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ