Molecular Biology and Morphology of Alternative Macroautophagy

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  • Shimizu Shigeomi
    東京医科歯科大学・難治疾患研究所・病態細胞生物
  • Arakawa Satoko
    東京医科歯科大学・難治疾患研究所・病態細胞生物
  • Nishida Yuya
    東京医科歯科大学・難治疾患研究所・病態細胞生物

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Other Title
  • Atg5非依存性オートファジーの形態学と分子生物学
  • Atg5 ヒイソンセイ オートファジー ノ ケイタイガク ト ブンシ セイブツガク

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Abstract

<p>Atg5 and Atg7 are considered as essential molecules for induction of macroautophagy. However, we found that cells lacking Atg5 or Atg7 can still form autophagosomes/autolysosomes and perform autophagy-mediated protein degradation when subjected to certain stresses. Although lipidation of LC3 is accepted to be a good indicator of macroautophagy, it did not occur during the Atg5/Atg7-independent alternative macroautophagy. Unlike conventional macroautophagy, autophagosomes seemed to be generated in a Rab9-dependent manner by the fusion of the phagophore with vesicles derived from the trans-Golgi and late endosomes. Mammalian macroautophagy can occur via at least two different pathways, which are an Atg5/Atg7-dependent conventional pathway and an Atg5/Atg7-independent alternative pathway.</p>

Journal

  • KENBIKYO

    KENBIKYO 45 (2), 94-96, 2010-06-30

    The Japanese Society of Microscopy

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