Food chemistry and physiological function of pseudovitamin B<sub>12</sub>

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  • Tanioka Yuri
    Department of Nutrition, Faculty of Applied Life Science, Tokyo University of Agriculture

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  • シュードビタミンB<sub>12</sub> の生理機能の解明と食品化学的研究
  • シュードビタミンB₁₂の生理機能の解明と食品化学的研究
  • シュードビタミン B ₁ ₂ ノ セイリ キノウ ノ カイメイ ト ショクヒン カガクテキ ケンキュウ

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Description

Vitamin B 12 (B 12 ) is synthesized only in certain bacteria． B 12 is concentrated mainly in the body of the higher predatory organisms in the natural food chain． Animal-derived foods such as meats， shellfish， egg， and milk are good dietary B 12 sources． In addition， a B 12 compound was contained abundantly in edible cyanobacteria． The B 12 compound present in edible cyanobacteria has been identified as pseudovitamin B 12 ， an inactive corrinoid compound for humans． Therefore， this study was attempted to clarify the physiological function of pseudovitamin B 12 in cyanobacteria． The full-length of Spirulina B 12 -dependent methionine synthase was cloned into E．coli to clarify the physiological function of pseudovitamin B 12 in cyanobacteria． The recombinant Spirulina enzyme showed a higher affinity for methylpseudovitamin B 12 than methylcobalamin as a cofactor， indicating that cyanobacateria can utilize pseudovitamin B 12 as the cofactor for B 12 -dependent methionine synthase．<br> 　It was further examined whether pseudovitamin B 12 exists in dietary sources other than edible cyanobacteria． As a result， a large amount of pseudovitamin B 12 was detected in turban shell and abalone， herbivorous sea snails． The content of B 12 in seaweeds which herbivorous sea snails consume as the food was very low， suggesting that pseudovitamin B 12 detected in herbivorous sea snails might be derived from cyanobacteria adhering to seaweeds．

Journal

  • VITAMINS

    VITAMINS 93 (2), 47-51, 2019-02-25

    THE VITAMIN SOCIETY OF JAPAN

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