Can Hyaluronic Acid Be Delivered in the Skin by Passive Diffusion?

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  • ヒアルロン酸などの水溶性高分子は塗布するだけで皮膚内部に送達できるか?
  • ヒアルロンサン ナド ノ スイヨウセイ コウブンシ ワ トフ スル ダケ デ ヒフ ナイブ ニ ソウタツ デキル カ?

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<p>In the pharmaceutical and health science area, transdermal drug delivery is a very important research and development area. Generally, skin is a barrier that protects the body from the outside. Generally, the properties of compounds that are advantageous for transdermal absorption are low molecular weight (<500 da) and high lipophilicity (octanol/water partition coefficients is about 1 to 2). Therefore, the skin permeability of the water-soluble compound is very low. However, consumers want to administer from the skin. In this article, the author described a novel technique for enhancement of percutaneous absorption of hyaluronic acid as a model of a water-soluble and high molecular weight compound. Specifically, hyaluronic acid nanoparticles (HANP) were prepared by the poly ion complex method. As a result, HANP was able to deliver HA into the skin by passive diffusion. I hope that these technologies can contribute to pharmaceutical and health science in the future.</p>

Journal

  • Oleoscience

    Oleoscience 20 (3), 135-139, 2020

    Japan Oil Chemists' Society

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