Primary hepatic neuroendocrine cancer coexisted with hepatocellular carcinoma: a case report

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  • Ebisutani Chikara
    Department of Gastroenterology and Hepatology, Hyogo Prefectural Kakogawa Medical Center
  • Yoon Seitetsu
    Department of Gastroenterology and Hepatology, Hyogo Prefectural Kakogawa Medical Center
  • Hyodo Toshiki
    Department of Diagnostic Pathology, Hyogo Prefectural Kakogawa Medical Center Department of Diagnostic Pathology, Kobe University Hospital
  • Watanabe Takafumi
    Department of Gastroenterology and Hepatology, Hyogo Prefectural Kakogawa Medical Center
  • Okada Hirofumi
    Department of Gastroenterology and Hepatology, Hyogo Prefectural Kakogawa Medical Center
  • Shirakawa Yutaka
    Department of Gastroenterology and Hepatology, Hyogo Prefectural Kakogawa Medical Center
  • Sakamoto Yoshio
    Department of Gastroenterology and Hepatology, Hyogo Prefectural Kakogawa Medical Center
  • Hirohata Shigeya
    Department of Gastroenterology and Hepatology, Hyogo Prefectural Kakogawa Medical Center

Bibliographic Information

Other Title
  • 肝細胞癌治療経過中に肝原発の神経内分泌癌を併発した症例
  • 症例報告 肝細胞癌治療経過中に肝原発の神経内分泌癌を併発した症例
  • ショウレイ ホウコク カン サイボウ ガン チリョウ ケイカ チュウ ニ カン ゲンパツ ノ シンケイ ナイブンピガン オ ヘイハツ シタ ショウレイ

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Description

<p>Primary hepatic neuroendocrine cancer (NEC) that coexisted with hepatocellular carcinoma (HCC) is very rare. Even though a 68-year-old woman with liver cirrhosis with HCC had been treated with transcatheter arterial chemo-embolism and radiation, her cancer progressed rapidly with metastasis, without AFP elevation. The autopsy result showed that she had primary hepatic NEC only, with lymph node and peritoneal metastases; however, she had no viable HCC. Her HCCs became necrotic with repeated treatment, but the viable NEC coexisted with necrotic tissue of the primary HCC. These findings suggest that NEC was transformed from tolerated HCC to newly occurring during repeated treatment.</p>

Journal

  • Kanzo

    Kanzo 61 (3), 122-128, 2020-03-01

    The Japan Society of Hepatology

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