<i>Kaempferia parviflora</i> (KP) reduced the visceral fat in mice

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  • Miyazaki Masaya
    Food chemistry/Functional food laboratory
  • Izumo Nobuo
    Yokohama University of Pharmacy General Health Medical Center Food chemistry/Functional food laboratory
  • Kuwahara Yu
    Food chemistry/Functional food laboratory
  • Sakurai Jun
    Food chemistry/Functional food laboratory
  • Honma Kazuto
    Food chemistry/Functional food laboratory
  • Hayamizu Kohsuke
    Food chemistry/Functional food laboratory
  • Nakano Makoto
    Yokohama University of Pharmacy General Health Medical Center Food chemistry/Functional food laboratory
  • Watanabe Yasuo
    Yokohama University of Pharmacy General Health Medical Center Food chemistry/Functional food laboratory

Abstract

<p>Kaempferia parviflora (KP) is a plant of the ginger family and has been used as a folk remedy in Thailand. Its rhizomes have been used to improve several diseases. However, the influence on visceral fat hasn't become clear. In this study, we searched for the mechanism of anti-obesity actions of KP. Method C57BL/6J male mice were used and the test feed was administered for 8 weeks. The dose of feed was limited (3g/day). Experimental groups were divided as follows, ①normal diet ②high fat diet (HF)　③HF + KP extraction 0.5% ④HF + KP extraction 1.0%. After 8 weeks of administration, visceral fat of mice was collected and weighed. In addition, expression levels of adiponectin, leptin, IL-6, IL-1β were measured by RT-PCR. Result The weight and the expression levels of leptin and IL-6 of visceral fat were significantly decreased in ③ and ④ groups compared with ②group, although the adiponectin levels did not show any changes. Conclusion Our results suggest that the mechanism of anti-obesity effects of KP is due to the induction of leptin resistance in a adipose tissues.</p>

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