胎生期ニコチン曝露による仔の行動変化:脳内ケモカインの関与

  • 木股 伶子
    名城大学薬学部薬品作用学
  • 間宮 隆吉
    名城大学薬学部薬品作用学 特定非営利活動法人医薬品適正使用推進機構
  • 竹河 里帆
    名城大学薬学部薬品作用学
  • 伊藤 愛
    名城大学薬学部薬品作用学
  • 衣斐 大祐
    名城大学薬学部薬品作用学
  • 鍋島 俊隆
    名城大学薬学部薬品作用学 藤田医科大学大学院医療科学専攻先進診断システム探索講座 特定非営利活動法人医薬品適正使用推進機構
  • 平松 正行
    名城大学薬学部薬品作用学 特定非営利活動法人医薬品適正使用推進機構

書誌事項

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  • Influences of prenatal nicotine exposure on behavioral functions of the offspring: Involvement of chemokine levels in the brain.

抄録

<p>The cigarette smoking during pregnancy is thought to induce the dysfunction of emotional and cognitive function of offspring. In our previous studies, we have reported that prenatal nicotine exposure affects the proliferation and maturation of progenitor cells to glutamatergic and dopaminergic neurons during neurodevelopment in the medial PFC, which may be associated with behavioral impairments in the offspring.  Recently, there is a hypothesis that inflammation during pregnancy might impair brain function of offspring. Here, we investigated whether prenatal nicotine exposure might affect the expression of chemokines in mice. </p><p> Pregnant mice were exposed to nicotine solution (0.2 mg/mL) dissolved in 2 % saccharin by drinking till embryonic day 14 (E14) to birth (P0) of offspring. On E15, 16, 18 and P1, we examined the protein levels of 10 chemokines in the brain. </p><p> The prenatal nicotine exposure increased the expression levels of CXCL1 and CCL2, but decreased those of CCL3, CCL4, CCL11 and CCL5 compared to those in the control on P1. It is suggested that prenatal nicotine exposure may influence the chemokine balance in the brain of offspring.</p>

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