書誌事項
- タイトル別名
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- Afferent Nerve Activity in Relation to Bladder Sensation
- ボウコウ キュウシンセイ シンケイ ノ ヤクリガクテキ キノウ カイセキ
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<p>Bladder afferent nerves are composed by myelinated Aδ- and unmyelinated C-fibers. During the storage phase of urine, distention of the bladder has long been considered to evoke afferent activity via Aδ-fibers connected in series with the smooth muscle fibers. In contrast, a previous study in cats revealed that more than 90% of C-fibers do not respond to normal bladder distension, being so called "silent" fibers. However, at least in rats, C-fibers can respond to normal bladder distension like Aδ-fibers, although they may also fulfill a potentially different role in the bladder sensory function in response to abnormal stimuli.</p><p>The symptoms of overactive bladder (OAB) or interstitial cystitis (IC) are believed to be commonly related to the sensory (afferent) function. In our laboratory, a direct measuring technique of mechanosensitive single-unit afferent activities of the primary bladder nerves in the rat has been established, and we have investigated the direct effects of drugs (anticholinergics, β3-adrenoceptor agonists, α1-adrenoceptor antagonists, PDE type5 inhibitors, etc.) on the bladder afferent function.</p><p>In this symposium, we will show some of our results and propose a possible additional action on sensory pathway of drugs as therapeutic agents for OAB or IC.</p>
収録刊行物
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- 日本薬理学会年会要旨集
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日本薬理学会年会要旨集 92 (0), 3-S25-2-, 2019
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390002184884414208
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- NII論文ID
- 130007745845
- 130007813383
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- NII書誌ID
- AN00198335
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- ISSN
- 24354953
- 13478397
- 00155691
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- NDL書誌ID
- 030077343
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- PubMed
- 31735754
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可