K<sub>ATP</sub>チャネルの遺伝的および薬理学的阻害はマウスの不安様行動を誘発する

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  • Genetical and pharmacological inhibition of ATP-sensitive potassium channels induces anxiety-like behavior in mice

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<p>Although Kir6.2, one of the subunits composed ATP-sensitive potassium (KATP) channels, are widely distributed in the brain, the roles in emotional behavior are not yet fully understood. Here we investigated the behavioral characteristics of Kir6.2-deficient (Kir6.2-/-) mice. Kir6.2-/- mice showed anxiety-like behavior in the elevated-plus maze test and light-dark test, especially, it was prominent in females. Immunohistochemical studies showed that Kir6.2 was co-localized with tryptophan hydroxylase (TPH) in the dorsal raphe nuclei and tyrosine hydroxylase (TH) in the ventral tegmental area/locus coeruleus. Interestingly, TPH expression in the midbrain was significantly elevated in female Kir6.2-/- mice. These results suggest that Kir6.2 expressed in serotonergic neurons could play a key role in emotional behavior. Furthermore, we investigated whether pharmacological blockade of KATP channels affects the emotional behavior. Mice that had been injected intracerebroventricularly with glibenclamide, a selective KATP channel blocker, showed anxiety-like behavior in the elevated-plus maze test. These results confirm a critical role of KATP channels in regulation of emotional behavior.</p>

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