Comparison of peripheral blood findings and postmortem brain findings in psychiatric disorders

  • Kinoshita Makoto
    Department of Psychiatry, Institute of Biomedical Science, Tokushima University Graduate School
  • Numata Shusuke
    Department of Psychiatry, Institute of Biomedical Science, Tokushima University Graduate School
  • Ohmori Tetsuro
    Department of Psychiatry, Institute of Biomedical Science, Tokushima University Graduate School

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Other Title
  • 精神疾患における末梢血所見と死後脳所見の比較
  • セイシン シッカン ニ オケル マッショウケツ ショケン ト シ コウノウ ショケン ノ ヒカク

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In Japan, Japan Brain Bank Net (JBBN) is currently operating by eight major brain banks, and postmortem brain research is expected to be conducted more actively in the future. On the other hand, studies using peripheral tissues that can be collected with relatively low invasiveness are also important for the researches of psychiatric disorders. However, in the studies using peripheral tissues, the significant of findings and the relationship between peripheral and central tissues are always questioned. In this article, we introduce our researches using peripheral blood samples derived from patients with psychiatric diseases. Furthermore, we introduce and discuss comparative studies of peripheral blood and postmortem brain studies. Since the findings obtained in both tissues are not always consistent, both approaches will be necessary to reveal the pathophysiology of psychiatric disorders and develop biomarkers.

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